Scientific opinion on the toxicological evaluation of phenol 2013 11(4):3189. 2016 90(6):1399–413.ĮFSA Panel on food contact materials, enzymes, flavourings processing aids. The involvement of TRP channels in sensory irritation: a mechanistic approach toward a better understanding of the biological effects of local irritants. Lehmann R, Schöbel N, Hatt H, van Thriel C. Cham: Springer International Publishing 2016. Spices and odorants as TRP channel activators-smell, taste, chemesthesis and beyond.
Guidance for industry-bioanalytical method validation. Solvent assisted flavour evaporation-a new and versatile technique for the careful and direct isolation of aroma compounds from complex food matrices. A generalization of the retention index system including linear temperature programmed gas-liquid partition chromatography. Survey and health assesment of chemicals substances in sex toys. Nilsson NH, Malmgren-Hansen B, Bernth N, Pedersen E, Pommer K. Chemical emissions from toys-the case of stink blasters. Tirendi S, Geiss O, Barrero-Moreno J, Kotzias D. Regulation (EC) No 1272/2008 of the European Parliament and of the Council of 16 December 2008 on classification, labelling and packaging of substances and mixtures. Characterization of odorants in inflatable aquatic toys and swimming learning devices-which substances are causative for the characteristic odor and potentially harmful? Anal Bioanal Chem. Likewise, phenol concentrations exceeded the LLOQ in 14 cases, with four samples containing elevated amounts ranging from about 140 to 280 mg/kg phenol. Thereby, six products contained between 0.3 and 1.6 g/kg isophorone and the remaining two samples contained even about 5 g/kg isophorone, each. Isophorone concentrations above the LLOQ were observed in eight samples. While some samples did not contain significant amounts of solvents, cyclohexanone concentrations above the lower limit of quantification (LLOQ) were determined in nine samples with six samples containing high concentrations ranging from about 1 to 7 g/kg cyclohexanone.
Furthermore, each sample was evaluated regarding its specific olfactory properties by an expert sensory panel. Extracts were then concentrated by Vigreux distillation and analysed by means of gas chromatography with mass spectrometric detection (GC-MS). Analytes were extracted with dichloromethane after the addition of non-labelled internal standards, and the volatile fraction was isolated using solvent-assisted flavour evaporation (SAFE). Based on the observation that the characteristic odour of inflatable aquatic toys for children is predominantly caused by residues of hazardous organic solvents, the concentrations of cyclohexanone, isophorone and phenol were determined in a selection of 20 products obtained from online suppliers located in Germany.
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